Apollo allows students to store and update their fosmid annotations in one XML file. Apollo offers many features that make it a desirable annotation tool, including the ability to keep track of evidence and annotations simultaneously, and built-in support for different types of evidence and annotation, all of which is highly customizable. Apollo also uses a graphical user interface which students find intuitive once oriented to its operation. At San Francisco State University, we also used some Perl scripts which allowed students to import new RepeatMasker, Tandem Repeat Finder, and BLAST results into their Apollo evidence tiers. We found that Apollo is a great tool for annotation, as tools with a graphical interface are more intuitive for students who are not computationally oriented.