Cindy Arrigo

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Genomics at New Jersey City University (Cindy Arrigo)

Course Overview

Implementation

Lessons Learned and Future Plans

Syllabus for SPRING 2015 MOLECULAR GENETICS BIOL 408 #158

           	 Instructor: 	Dr. Cindy Jo Arrigo


SPRING 2015 MOLECULAR GENETICS BIOL 408 #1589
Tuesday and Thursday evenings from 6-8:45pm

Instructor: Dr. Cindy Jo Arrigo
Office: S341, Lab: S314
Office hours: Tue and Thu 3-5, Wed 12-2
Contact: carrigo@njcu.edu; 201.200.2341
Course Meetings: Science Building 314 (wet bench) Computer suite (computation)


OPEN SOURCE TEXTS: Molecular Biology of the Cell, Alberts B, Johnson A, Lewis J, et al
Genomes, Brown, TA
Human Molecular Genetics, Stachan T, and Read AP
Genes and Disease, National Center for Biotechnology Information


COURSE DESCRIPTION: This lecture plus lab course examines the physical and biological properties of nucleic acids. DNA replication, gene expression, recombination, mutation and DNA repair are presented. The laboratory component introduces students to the techniques of recombinant DNA technology and functional genomics.

LEARNING GOALS: This course supports discipline, critical thinking and literacy goals of the department of biology as well as the following University-Wide Student Learning Goals: Students will demonstrate effective writing skills, Students will demonstrate effective oral communication skills, Students will demonstrate the ability to think critically to evaluate and solve problems, Students will demonstrate effective information and technology literacy skills.

LEARNING OUTCOMES: By the end of the course students will be able to interpret DNA organization from a whole organism and evolutionary perspective, analyze molecular genetics problems and make implications and draw conclusions from the analyses, apply molecular genetic technologies to research questions, design and successfully execute a research project in molecular genetics and communicate their experimental findings orally and in scientific format.

EVALUATIONS: THREE tests (15% each);
ONE Research Project (35%) and its oral defense (10%);
Assignments and lab documentation (10%).

ATTENDANCE: Attendance is mandatory. Students are expected to attend each course session. A student’s final average and semester grade will be adversely affected by excessive absences.

If you have special needs or would like to request accommodations because of learning disabilities or other disabilities please contact the Office of Specialized Services @ 201-200-2557.

BIOL 408 LECTURE/LAB SCHEDULE SPRING 2015



PART 1: CHEMISTRY, GENETICS, CELL NUCLEUS, GENOME (Weeks 1-7)

Weak Chemical Interactions, High-Energy Bonds, Macromolecular Structure
Classical Genetics, Molecules of Genetics
The Structures of DNA and RNA
Test February 3rd
Nucleus Structure and Function
Genome Structure, Chromatin, the Nucleosome
Lab: Chromatin Structure
Isolate and characterize animal nucleosomes
Test February 19th
Replication, Segregation, Mutability and Repair of DNA Lab: Genetic Engineering
Construct and characterize a viral library
Homologous Recombination
Recombinant DNA technologies


SPRING BREAK: March 9-14


PART 2: GENOME EXPRESSION, INTERPRETATION, APPLICATION (Weeks 9-16)

Mechanisms of Transcription
RNA Splicing, Translation, The Genetic Code Regulation of Gene Expression
Test March 24th
Lab: Animal Genome Mapping
Computational – Recombinant DNA technologies
Genome Analysis and Systems Biology
Gene Regulation in Development and Evolution Genome Sequencing, techniques, emerging practices
Oral Defense sessions, April 30, 2015 Detecting and Interpreting Genetic Homology
Final Project submissions, May 5, 2015
Annotation Introduction and Strategies Independent Annotation Research Posters